. Macleaya cordata extract contains sanguinaine and chelerythrine, which have fungicidal and insecticidal activity. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. Macleaya cordata contains several alkaloids including sanguinarine, chelerythrine, protopine, and allocryptopine. Our product, Macleaya cordata extract mainly constains with sanguinarine and chelerythrine. It was been show to be reversible inhibitors of t