date:Jan 21, 2013
ty of Florida College of Pharmacy. Derendorf was not involved in the Canadian review.
If the drug is metabolized in the gut wall to a large extent and this metabolism is blocked, then the concentrations in the blood will go up. An example is the lipid-lowering drug simvastatin (Zocor), says Derendorf. For other drugs such as the antihistamine fexofenadine (Allegra), grapefruit juice blocks the uptake into the bloodstream and the concentrations in blood will go down.
In all such cases there are