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Protein missing in fat tissue ‘favours bad over good fat’
date:Jan 07, 2013
such as the central nervous system, the liver, or muscle. In every case, the mice were normal. They werent obese like the mice lacking p62 everywhere.

Then they made a mouse model lacking p62 only in their fat tissue. These mice were obese, just like the mice missing p62 in all tissues. Upon further study, the researchers found that p62 blocks the action of an enzyme called ERK while activating another enzyme called p38. When p62 is missing, the enzyme p38 is less active in brown fat, while ERK

12/22 18:20